8GWF

A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	RNA-directed RNA polymerase	polymer	932	106781.0	1	UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) In PDB	Severe acute respiratory syndrome coronavirus 2	Pol, RdRp, Non-structural protein 12, nsp12
2	B, D	Non-structural protein 8	polymer	198	21903.0	2	UniProt (P0DTD1) Pfam (PF08717) In PDB	Severe acute respiratory syndrome coronavirus 2	nsp8
3	C	Non-structural protein 7	polymer	83	9248.8	1	UniProt (P0DTC1) Pfam (PF08716) UniProt (by SIFTS) (P0DTD1) In PDB	Severe acute respiratory syndrome coronavirus 2	nsp7
4	I	primer	polymer	25	8172.9	1		Severe acute respiratory syndrome coronavirus 2
5	J	template	polymer	33	10443.2	1		Severe acute respiratory syndrome coronavirus 2
6	F, E	Helicase	polymer	601	66930.5	2	UniProt (P0DTD1) Pfam (PF20632) Pfam (PF20633) Pfam (PF20631) Pfam (PF13087) In PDB	Severe acute respiratory syndrome coronavirus 2	Hel, Non-structural protein 13, nsp13
7	G	Non-structural protein 9	polymer	117	12794.6	1	UniProt (P0DTD1) Pfam (PF08710) In PDB	Severe acute respiratory syndrome coronavirus 2	nsp9
8	A, F, E	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
9	A	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
10		water	water		18.0	1	Chemie (HOH)

Sequence modifications

G: 1 - 113 (UniProt: P0DTD1)

PDB	External Database	Details
Ser -3	-	expression tag
Asn -2	-	expression tag
Ala -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	325107.7
Non-Polymers*	Number of molecules	9
	Total formula weight	1046.5
All*	Total formula weight	326154.2

*Water molecules are not included.