8GW1
A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analogue inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Replicase polyprotein 1ab | polymer | 942 | 108161.5 | 1 | UniProt (P0DTD1) Pfam (PF06478) Pfam (PF00680) | Severe acute respiratory syndrome coronavirus 2 | pp1ab,ORF1ab polyprotein,nsp12 |
| 2 | B, D (B, D) | Non-structural protein 8 | polymer | 198 | 21903.0 | 2 | UniProt (P0DTD1) Pfam (PF08717) | Severe acute respiratory syndrome coronavirus 2 | nsp8 |
| 3 | C (C) | Non-structural protein 7 | polymer | 83 | 9248.8 | 1 | UniProt (P0DTC1) Pfam (PF08716) UniProt (by SIFTS) (P0DTD1) | Severe acute respiratory syndrome coronavirus 2 | nsp7 |
| 4 | E (I) | RNA (25-MER) | polymer | 25 | 8172.9 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 5 | F (J) | Template | polymer | 26 | 8215.9 | 1 | Severe acute respiratory syndrome coronavirus 2 | ||
| 6 | G, H (E, F) | Helicase | polymer | 601 | 66930.5 | 2 | UniProt (P0DTD1) Pfam (PF20632) Pfam (PF20633) Pfam (PF20631) Pfam (PF13087) | Severe acute respiratory syndrome coronavirus 2 | Hel, Non-structural protein 13, nsp13 |
| 7 | I (G) | Non-structural protein 9 | polymer | 113 | 12391.2 | 1 | UniProt (P0DTD1) Pfam (PF08710) | Severe acute respiratory syndrome coronavirus 2 | nsp9 |
| 8 | J, K, N, O, P... (A, E, F) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 9 | L, M (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 10 | T (G) | URIDINE-5'-MONOPHOSPHATE | non-polymer | 324.2 | 1 | Chemie (U5P) | |||
| 11 | U, V (A, G) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 1 - 932 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Asn 910 | Asp 5302 | engineered mutation |
| His 933 | - | expression tag |
| His 934 | - | expression tag |
| His 935 | - | expression tag |
| His 936 | - | expression tag |
| His 937 | - | expression tag |
| His 938 | - | expression tag |
| His 939 | - | expression tag |
| His 940 | - | expression tag |
| His 941 | - | expression tag |
| His 942 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 323857.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 957.3 | |
| All* | Total formula weight | 324814.8 |
