8GUY
human insulin receptor bound with two insulin molecules
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | E, F | Isoform Short of Insulin receptor | polymer | 907 | 103623.6 | 2 | UniProt (P06213) Pfam (PF01030) Pfam (PF00757) Pfam (PF00041) In PDB | Homo sapiens (human) | IR |
2 | A, C | Insulin A chain | polymer | 21 | 2383.7 | 2 | UniProt (P01308) In PDB | Homo sapiens (human) | Small chain |
3 | B, D | Insulin, isoform 2 | polymer | 25 | 2860.3 | 2 | UniProt (F8WCM5) In PDB | Homo sapiens (human) | INS-IGF2 readthrough transcript protein |
Sequence modifications
E, F: 1 - 907 (UniProt: P06213)
PDB | External Database | Details |
---|---|---|
His 144 | Tyr 171 | engineered mutation |
Thr 421 | Ile 448 | engineered mutation |
Lys 465 | Gln 492 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 217735.1 | |
All* | Total formula weight | 217735.1 |