8GRG
Crystal structure of a constitutively active mutant of the alpha gamma heterodimer of human IDH3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Human IDH3 alpha subunit | polymer | 339 | 36625.1 | 1 | UniProt (P50213) Pfam (PF00180) | Homo sapiens (human) | |
| 2 | B (B) | Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial | polymer | 354 | 38867.5 | 1 | UniProt (P51553) Pfam (PF00180) | Homo sapiens (human) | NAD-IDH gamma subunit, Isocitric dehydrogenase subunit gamma,NAD(+)-specific ICDH subunit gamma |
| 3 | C, D (A, B) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 1 - 339 (UniProt: P50213)
| PDB | External Database | Details |
|---|---|---|
| Ala 139 | Gln 166 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75492.6 | |
| All* | Total formula weight | 75492.6 |
