8GMD
CRYSTAL STRUCTURE OF AP2 ASSOCIATED KINASE 1 COMPLEXED WITH (5P)-3-({(8R)-5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-[2-(propan-2-yl)-2H-tetrazol-5-yl]phenol
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | AP2-associated protein kinase 1 | polymer | 318 | 36095.4 | 2 | UniProt (Q2M2I8) Pfam (PF00069) In PDB | Homo sapiens (human) | Adaptor-associated kinase 1 |
2 | A, B | (5P)-3-({(8R)-5-[(4-aminopiperidin-1-yl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-yl}amino)-5-[2-(propan-2-yl)-2H-tetrazol-5-yl]phenol | non-polymer | 448.5 | 2 | Chemie (ZRR) | |||
3 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
4 | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 26 - 330 (UniProt: Q2M2I8)
PDB | External Database | Details |
---|---|---|
Met 13 | - | expression tag |
His 14 | - | expression tag |
His 15 | - | expression tag |
His 16 | - | expression tag |
His 17 | - | expression tag |
His 18 | - | expression tag |
His 19 | - | expression tag |
Leu 20 | - | expression tag |
Val 21 | - | expression tag |
Pro 22 | - | expression tag |
Arg 23 | - | expression tag |
Gly 24 | - | expression tag |
Ser 25 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 72190.8 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 1377.4 | |
All* | Total formula weight | 73568.1 |