8GM5
Functional construct of the Eukaryotic elongation factor 2 kinase bound to Calmodulin, ADP and to the A-484954 inhibitor and showing two conformations for the 498-520 loop
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Eukaryotic elongation factor 2 kinase | polymer | 531 | 60380.7 | 1 | UniProt (O00418) Pfam (PF02816) | Homo sapiens (human) | eEF-2 kinase,eEF-2K,Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase |
| 2 | B (B) | Calmodulin-1 | polymer | 148 | 16721.3 | 1 | UniProt (P0DP23) Pfam (PF13499) | Homo sapiens (human) | |
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | 7-amino-1-cyclopropyl-3-ethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-6-carboxamide | non-polymer | 289.3 | 1 | Chemie (EKI) | |||
| 5 | E (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 6 | F, G (B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 7 | H, I (A, B) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A: 70 - 483 (UniProt: O00418)
A: 490 - 725 (UniProt: O00418)
A: 490 - 725 (UniProt: O00418)
| PDB | External Database | Details |
|---|---|---|
| Gly 484 | - | linker |
| Gly 485 | - | linker |
| Gly 486 | - | linker |
| Gly 487 | - | linker |
| Gly 488 | - | linker |
| Gly 489 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77102.1 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 862.1 | |
| All* | Total formula weight | 77964.1 |
