8GLS
Complex of human cystic fibrosis transmembrane conductance regulator (CFTR) and Z1834339853
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cystic fibrosis transmembrane conductance regulator | polymer | 1480 | 168334.5 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | B (B) | human cystic fibrosis transmembrane conductance regulator | polymer | 17 | 1464.8 | 1 | Homo sapiens | ||
| 3 | C, D (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | E, F (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | G, H, I, J, K (A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) | |||
| 6 | L (A) | (2S)-1-(3-amino-6-fluoro-1H-indazol-1-yl)-2-methyl-3-phenoxypropan-1-one | non-polymer | 313.3 | 1 | Chemie (ZRH) |
Sequence modifications
A: 1 - 1480 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 169799.3 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5176.7 | |
| All* | Total formula weight | 174975.9 |
