8GKU

Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF355 inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Serine hydroxymethyltransferase, mitochondrial	polymer	493	54605.9	2	UniProt (P34897) Pfam (PF00464)	Homo sapiens (human)	SHMT,Glycine hydroxymethyltransferase,Serine methylase
2	C (A)	N-{4-[5-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)pentyl]-2-fluorobenzoyl}-D-glutamic acid	non-polymer		487.5	1	Chemie (ZV1)
3	D (A)	GLYCINE	non-polymer		75.1	1	Chemie (GLY)
4	E, F (A, B)	PYRIDOXAL-5'-PHOSPHATE	non-polymer		247.1	2	Chemie (PLP)
5	G, H (A, B)	water	water		18.0	69	Chemie (HOH)

Sequence modifications

A, B: 29 - 504 (UniProt: P34897)

PDB	External Database	Details
Met 12	-	initiating methionine
Gly 13	-	expression tag
Ser 14	-	expression tag
Ser 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
Ser 22	-	expression tag
Ser 23	-	expression tag
Gly 24	-	expression tag
Leu 25	-	expression tag
Val 26	-	expression tag
Pro 27	-	expression tag
Arg 28	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	109211.9
Non-Polymers*	Number of molecules	4
	Total formula weight	1056.8
All*	Total formula weight	110268.7

*Water molecules are not included.