8GKC
Atomic model of the core modifying region of human fatty acid synthase in complex with TVB-2640 - C2 refinement
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, D) | Fatty acid synthase | polymer | 1670 | 182749.0 | 2 | UniProt (P49327) Pfam (PF21089) Pfam (PF08242) Pfam (PF21149) Pfam (PF00107) Pfam (PF08659) Pfam (PF00550) Pfam (PF00975) | Homo sapiens (human) | Type I fatty acid synthase |
| 2 | C, F (A, D) | denifanstat | non-polymer | 439.6 | 2 | Chemie (X5O) | |||
| 3 | D, E, G, H (A, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) |
Sequence modifications
A, D: 855 - 2511 (UniProt: P49327)
| PDB | External Database | Details |
|---|---|---|
| Gly 854 | - | cloning artifact |
| Leu 2512 | - | cloning artifact |
| Glu 2513 | - | cloning artifact |
| Ser 2514 | - | cloning artifact |
| Arg 2515 | - | cloning artifact |
| Gly 2516 | - | cloning artifact |
| Pro 2517 | - | cloning artifact |
| His 2518 | - | expression tag |
| His 2519 | - | expression tag |
| His 2520 | - | expression tag |
| His 2521 | - | expression tag |
| His 2522 | - | expression tag |
| His 2523 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 365498.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 3860.8 | |
| All* | Total formula weight | 369358.8 |
