8GIT
Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 1mM Mn2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, C) | Cyclic GMP-AMP synthase | polymer | 364 | 42640.3 | 2 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (house mouse) | cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | C, D, E, F (E, F, I, J) | Palindromic DNA18 | polymer | 18 | 5514.6 | 4 | synthetic construct | ||
| 3 | G, K (A, C) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 4 | H, L (A, C) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | I, J, M, N (A, C) | MANGANESE (II) ION | non-polymer | 54.9 | 4 | Chemie (MN) | |||
| 6 | O, P, Q (A, C, F) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
A, C: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Gly 144 | - | expression tag |
| Thr 145 | - | expression tag |
| Gly 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 107338.9 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1364.9 | |
| All* | Total formula weight | 108703.9 |
