8GGW
Locally refined cryoEM structure of receptor from beta-2-adrenergic receptor in complex with GTP-bound Gs heterotrimer (transition intermediate #15 of 20)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | Beta-2 adrenergic receptor | polymer | 460 | 51767.2 | 1 | UniProt (P07550) Pfam (PF00001) In PDB | Homo sapiens (human) | Beta-2 adrenoreceptor,Beta-2 adrenoceptor |
2 | R | (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol | non-polymer | 209.2 | 1 | Chemie (G1I) |
Sequence modifications
R: -6 - 421 (UniProt: P07550)
PDB | External Database | Details |
---|---|---|
Met -30 | - | expression tag |
Lys -29 | - | expression tag |
Thr -28 | - | expression tag |
Ile -27 | - | expression tag |
Ile -26 | - | expression tag |
Ala -25 | - | expression tag |
Leu -24 | - | expression tag |
Ser -23 | - | expression tag |
Tyr -22 | - | expression tag |
Ile -21 | - | expression tag |
Phe -20 | - | expression tag |
Cys -19 | - | expression tag |
Leu -18 | - | expression tag |
Val -17 | - | expression tag |
Phe -16 | - | expression tag |
Ala -15 | - | expression tag |
Asp -14 | - | expression tag |
Tyr -13 | - | expression tag |
Lys -12 | - | expression tag |
Asp -11 | - | expression tag |
Asp -10 | - | expression tag |
Asp -9 | - | expression tag |
Asp -8 | - | expression tag |
Ala -7 | - | expression tag |
Arg 9 | Gly 16 | variant |
Glu 18 | - | insertion |
Asn 19 | - | insertion |
Leu 20 | - | insertion |
Tyr 21 | - | insertion |
Phe 22 | - | insertion |
Gln 23 | - | insertion |
Gly 24 | - | insertion |
Gln 27 | Glu 27 | variant |
Thr 96 | Met 96 | conflict |
Thr 98 | Met 98 | conflict |
Glu 187 | Asn 187 | conflict |
Leu 366 | - | insertion |
Glu 367 | - | insertion |
Val 368 | - | insertion |
Leu 369 | - | insertion |
Phe 370 | - | insertion |
Gln 371 | - | insertion |
Gly 372 | - | insertion |
Pro 373 | - | insertion |
Ala 386 | Cys 378 | conflict |
Ala 414 | Cys 406 | conflict |
Glu 422 | - | expression tag |
Thr 423 | - | expression tag |
Ser 424 | - | expression tag |
Gln 425 | - | expression tag |
Val 426 | - | expression tag |
Ala 427 | - | expression tag |
Pro 428 | - | expression tag |
Ala 429 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 51767.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 209.2 | |
All* | Total formula weight | 51976.5 |