8GDS

CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH 4-(4-(2-(2,3-DIHYDRO-1H- INDOL-1-YL)-2-OXOETHYL)PHENYL)-1(2H)-PHTHALAZINONE

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Rho-associated protein kinase 2	polymer	396	45471.7	4	UniProt (O75116) Pfam (PF00069) In PDB	Homo sapiens (human)	Rho kinase 2,Rho-associated,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2
2	A, B, C, D	4-{4-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]phenyl}phthalazin-1(2H)-one	non-polymer		381.4	4	Chemie (Z8O)
3	A, B, C, D	SULFATE ION	non-polymer		96.1	17	Chemie (SO4)
4		water	water		18.0	43	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	181886.9
Non-Polymers*	Number of molecules	21
	Total formula weight	3158.8
All*	Total formula weight	185045.7

*Water molecules are not included.