8GDC
Cryo-EM Structure of the Prostaglandin E2 Receptor 3 Coupled to G Protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40445.1 | 1 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (human) | Transducin beta chain 1 |
| 3 | C (C) | Guanine nucleotide-binding protein subunit gamma | polymer | 108 | 12104.9 | 1 | UniProt (A0A7J7XNR4) Pfam (PF00631) UniProt (by SIFTS) (P59768) | Homo sapiens (human) | |
| 4 | D (R) | Prostaglandin E2 receptor EP3 subtype | polymer | 390 | 43357.7 | 1 | UniProt (P43115) Pfam (PF00001) | Homo sapiens (human) | PGE receptor EP3 subtype,PGE2 receptor EP3 subtype,PGE2-R,Prostanoid EP3 receptor |
| 5 | E (R) | (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxo-cyclopentyl]hept-5-enoic acid | non-polymer | 352.5 | 1 | Chemie (P2E) PubChem (16219826) PubChem (71195864) PubChem (176729059) PubChem (177546178) PubChem (35021823) PubChem (35021833) PubChem (26436117) PubChem (40575690) PubChem (35027359) PubChem (40575698) PubChem (44444717) PubChem (49822699) PubChem (91886115) PubChem (5280360) PubChem (97041839) PubChem (53477468) PubChem (54466054) PubChem (54466055) PubChem (54466056) PubChem (54466057) PubChem (57357999) PubChem (12314587) PubChem (156359195) PubChem (171042408) PubChem (59294054) PubChem (59881728) PubChem (59926133) PubChem (59941509) PubChem (59968515) PubChem (67937739) PubChem (70419675) PubChem (71082424) PubChem (71401211) PubChem (73357245) PubChem (90689772) PubChem (90798199) PubChem (91019309) PubChem (92450042) PubChem (92966520) PubChem (97041838) PubChem (158) PubChem (122176715) PubChem (9691) PubChem (122702174) PubChem (123841661) PubChem (122348) PubChem (124350425) PubChem (124406582) PubChem (124406583) PubChem (124524501) PubChem (3246816) PubChem (3246832) PubChem (5283061) PubChem (5283086) PubChem (5283116) PubChem (5283213) PubChem (5353587) PubChem (6445999) PubChem (6450019) PubChem (9874974) PubChem (9950404) PubChem (10247450) PubChem (11221902) PubChem (11581143) PubChem (12041746) PubChem (12314577) PubChem (12314580) PubChem (12314582) PubChem (12314584) PubChem (12314585) PubChem (12314588) PubChem (12314590) PubChem (12314594) PubChem (131954610) PubChem (139503973) PubChem (149202340) PubChem (154166399) PubChem (155114512) PubChem (156358885) PubChem (156359009) PubChem (156681952) PubChem (156681960) PubChem (162705518) PubChem (163091488) PubChem (163091489) PubChem (166639831) PubChem (166639839) PubChem (166639992) PubChem (169502219) PubChem (171157690) PubChem (172878425) PubChem (173974797) PubChem (175594575) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
C: -9 - 71 (UniProt: A0A7J7XNR4)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | conflict |
| Ser 326 | Ala 326 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | expression tag |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Leu -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Val -8 | - | expression tag |
| Leu -7 | - | expression tag |
| Phe -6 | - | expression tag |
| Gln -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Gly 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met -36 | - | expression tag |
| Trp -35 | - | expression tag |
| Arg -34 | - | expression tag |
| Glu -33 | - | expression tag |
| Leu -32 | - | expression tag |
| Pro -31 | - | expression tag |
| Leu -30 | - | expression tag |
| Gly -29 | - | expression tag |
| Leu -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Glu -26 | - | expression tag |
| Leu -25 | - | expression tag |
| His -24 | - | expression tag |
| Lys -23 | - | expression tag |
| Asp -22 | - | expression tag |
| His -21 | - | expression tag |
| Gln -20 | - | expression tag |
| Ala -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Arg -17 | - | expression tag |
| Lys -16 | - | expression tag |
| Leu -15 | - | expression tag |
| Glu -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Glu -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Trp -10 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 135325.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 352.5 | |
| All* | Total formula weight | 135678.2 |
