8GCC
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA topoisomerase 2 | polymer | 779 | 89322.4 | 2 | UniProt (Q4DE53) Pfam (PF16898) Pfam (PF00521) | Trypanosoma cruzi strain CL Brener | |
| 2 | C, D (C, D) | DNA (28-MER) | polymer | 28 | 8604.6 | 2 | Escherichia coli | ||
| 3 | E, F (C, D) | 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one | non-polymer | 398.3 | 2 | Chemie (YWX) |
Sequence modifications
A, B: 401 - 1178 (UniProt: Q4DE53)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 195854.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 796.7 | |
| All* | Total formula weight | 196650.7 |
