8GC8
Bruton's tyrosine kinase L528W mutant in complex with 5-(piperidin-1-yl)-3-{[4-(piperidin-4-yl)phenyl]amino}pyrazine-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase BTK | polymer | 270 | 31584.3 | 1 | UniProt (Q06187) Pfam (PF07714) In PDB | Homo sapiens (human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | A | 5-(piperidin-1-yl)-3-[4-(piperidin-4-yl)anilino]pyrazine-2-carboxamide | non-polymer | 380.5 | 1 | Chemie (YXJ) | |||
| 3 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 133 | Chemie (HOH) |
Sequence modifications
A: 389 - 658 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Trp 528 | Leu 528 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31584.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 690.8 | |
| All* | Total formula weight | 32275.1 |
