8GAV

Structure of human NDS.3 Fab in complex with influenza virus neuraminidase from A/Darwin/09/2021 (H3N2)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Neuraminidase	polymer	467	51972.3	1	UniProt (A0A8F5JTQ6) Pfam (PF00064) UniProt (by SIFTS) (A0A5B9C3Z7)	Influenza A virus
2	B (H)	Fab NDS.3, heavy chain	polymer	227	24209.2	1		Homo sapiens (human)
3	C (L)	Fab NDS.3, light chain	polymer	216	22863.1	1		Homo sapiens (human)
4	D, E, F (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)

Sequence modifications

A: 83 - 469 (UniProt: A0A8F5JTQ6)

PDB	External Database	Details
Met 3	-	expression tag
Glu 4	-	expression tag
Phe 5	-	expression tag
Gly 6	-	expression tag
Leu 7	-	expression tag
Ser 8	-	expression tag
Trp 9	-	expression tag
Ile 10	-	expression tag
Phe 11	-	expression tag
Leu 12	-	expression tag
Ala 13	-	expression tag
Ala 14	-	expression tag
Ile 15	-	expression tag
Leu 16	-	expression tag
Lys 17	-	expression tag
Gly 18	-	expression tag
Val 19	-	expression tag
Gln 20	-	expression tag
Cys 21	-	expression tag
Ala 22	-	expression tag
Asp 23	-	expression tag
Pro 24	-	expression tag
His 25	-	expression tag
His 26	-	expression tag
His 27	-	expression tag
His 28	-	expression tag
His 29	-	expression tag
His 30	-	expression tag
His 31	-	expression tag
His 32	-	expression tag
Ser 33	-	expression tag
Ser 34	-	expression tag
Ser 35	-	expression tag
Asp 36	-	expression tag
Arg 37	-	expression tag
Phe 38	-	expression tag
Asp 39	-	expression tag
Val 40	-	expression tag
Asp 41	-	expression tag
Lys 42	-	expression tag
Leu 43	-	expression tag
Lys 44	-	expression tag
Gln 45	-	expression tag
Glu 46	-	expression tag
Ile 47	-	expression tag
Met 48	-	expression tag
Thr 49	-	expression tag
Glu 50	-	expression tag
Ile 51	-	expression tag
Arg 52	-	expression tag
Arg 53	-	expression tag
Glu 54	-	expression tag
Val 55	-	expression tag
Ser 56	-	expression tag
Lys 57	-	expression tag
Met 58	-	expression tag
Lys 59	-	expression tag
Gln 60	-	expression tag
Asp 61	-	expression tag
Ile 62	-	expression tag
Ile 63	-	expression tag
Glu 64	-	expression tag
Ala 65	-	expression tag
Ile 66	-	expression tag
Lys 67	-	expression tag
Val 68	-	expression tag
Glu 69	-	expression tag
Leu 70	-	expression tag
Asn 71	-	expression tag
Arg 72	-	expression tag
Gly 73	-	expression tag
Ser 74	-	expression tag
Leu 75	-	expression tag
Val 76	-	expression tag
Pro 77	-	expression tag
Arg 78	-	expression tag
Gly 79	-	expression tag
Ser 80	-	expression tag
Gly 81	-	expression tag
Gly 82	-	expression tag
Ser 150	Arg 150	conflict

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	99044.7
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	99708.3

*Water molecules are not included.