8G9V

Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	17-beta-hydroxysteroid dehydrogenase 13	polymer	315	35502.3	8	UniProt (Q7Z5P4) Pfam (PF00106)	Homo sapiens (human)	17-beta-HSD 13,Short chain dehydrogenase/reductase family 16C member 3,Short-chain dehydrogenase/reductase 9
2	CA, FA, I, KA, N... (E, F, A, G, B...)	NICOTINAMIDE-ADENINE-DINUCLEOTIDE	non-polymer		663.4	8	Chemie (NAD)
3	DA, GA, J, LA, O... (E, F, A, G, B...)	4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid	non-polymer		459.5	8	Chemie (YYC)
4	AA, BA, K, T (D, E, A, C)	O-DODECANYL OCTAETHYLENE GLYCOL	non-polymer		538.8	4	Chemie (CE1)
5	EA, HA, IA, JA, L... (E, F, A, G, B...)	SULFATE ION	non-polymer		96.1	17	Chemie (SO4)
6	TA, UA, VA, WA, XA... (A, B, C, D, E...)	water	water		18.0	23	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 2 - 300 (UniProt: Q7Z5P4)

PDB	External Database	Details
Met 0	-	initiating methionine
Gly 1	-	cloning artifact
Lys 60	Gln 60	engineered mutation
Arg 62	Ile 62	engineered mutation
His 71	Arg 71	engineered mutation
Lys 161	Glu 161	engineered mutation
Gly 301	-	expression tag
Ser 302	-	expression tag
Gly 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag
His 306	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	284018.8
Non-Polymers*	Number of molecules	37
	Total formula weight	12771.8
All*	Total formula weight	296790.6

*Water molecules are not included.