8G9P
Tricomplex of RMC-4998, KRAS G12C, and CypA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | GTPase KRas | polymer | 170 | 19404.9 | 2 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | C, D | Peptidyl-prolyl cis-trans isomerase A | polymer | 166 | 18123.6 | 2 | UniProt (P62937) Pfam (PF00160) In PDB | Homo sapiens (human) | PPIase A,Cyclophilin A,Cyclosporin A-binding protein,Rotamase A |
3 | A, B | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 2 | Chemie (GNP) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A, B | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
6 | C, D | (2S)-2-{(5S)-7-[(2E)-4-(dimethylamino)-4-methylpent-2-enoyl]-1-oxo-2,7-diazaspiro[4.4]nonan-2-yl}-N-[(1P,8S,10R,14S,21M)-22-ethyl-21-{2-[(1S)-1-methoxyethyl]pyridin-3-yl}-18,18-dimethyl-9,15-dioxo-16-oxa-10,22,28-triazapentacyclo[18.5.2.1~2,6~.1~10,14~.0~23,27~]nonacosa-1(25),2(29),3,5,20,23,26-heptaen-8-yl]-3-methylbutanamide (non-preferred name) | non-polymer | 985.3 | 2 | Chemie (YV2) | |||
7 | water | water | 18.0 | 999 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 169 (UniProt: P01116)
C, D: 1 - 165 (UniProt: P62937)
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
Cys 12 | Gly 12 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 75057.0 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3134.4 | |
All* | Total formula weight | 78191.5 |