8G7T

Cryo-EM structure of Riplet:RIG-I:dsRNA complex (end-end)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Antiviral innate immune response receptor RIG-I	polymer	925	106740.6	2	UniProt (O95786) Pfam (PF16739) Pfam (PF00270) Pfam (PF18119) Pfam (PF00271) Pfam (PF11648) In PDB	Homo sapiens (human)	DEAD box protein 58,Probable ATP-dependent RNA helicase DDX58,RIG-I-like receptor 1,RLR-1,Retinoic acid-inducible gene 1 protein,RIG-1,Retinoic acid-inducible gene I protein,RIG-I
2	B, D	E3 ubiquitin-protein ligase RNF135	polymer	432	47946.3	2	UniProt (Q8IUD6) Pfam (PF15227) Pfam (PF00622) In PDB	Homo sapiens (human)	RIG-I E3 ubiquitin ligase,REUL,RING finger protein 135,RING finger protein leading to RIG-I activation,Riplet,RING-type E3 ubiquitin transferase RNF135
3	X	p3dsRNA24a	polymer	24	7885.6	1		Homo sapiens
4	Y	p3dsRNA24b	polymer	24	7788.6	1		Homo sapiens
5	A, C	ZINC ION	non-polymer		65.4	2	Chemie (ZN)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	325047.9
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	325178.7

*Water molecules are not included.