8G59
Cryo-EM structure of the TUG891 bound GPR120-Giq complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
| 2 | Y | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
| 3 | S | scFv16 | polymer | 285 | 30363.0 | 1 | Homo sapiens (human) | ||
| 4 | A | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 354 | 40555.2 | 1 | UniProt (P63096) UniProt (P50148) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein,Guanine nucleotide-binding protein alpha-q |
| 5 | R | Free fatty acid receptor 4 | polymer | 361 | 40533.2 | 1 | UniProt (Q5NUL3) Pfam (PF00001) In PDB | Homo sapiens (human) | G-protein coupled receptor 120,G-protein coupled receptor 129,G-protein coupled receptor GT01,G-protein coupled receptor PGR4,Omega-3 fatty acid receptor 1 |
| 6 | R | 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid | non-polymer | 364.4 | 1 | Chemie (YN9) |
Sequence modifications
A: 1 - 331 (UniProt: P63096)
A: 332 - 359 (UniProt: P50148)
| PDB | External Database | Details |
|---|---|---|
| Ala 203 | Gly 203 | engineered mutation |
| Ser 331 | Ala 326 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 156598.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 364.4 | |
| All* | Total formula weight | 156962.7 |
