8G4T
Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, F | Envelope glycoprotein BG505 DS-SOSIP gp41 | polymer | 153 | 17162.5 | 3 | UniProt (Q2N0S7) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
| 2 | C, G, I | Envelope glycoprotein BG505 DS-SOSIP gp120 | polymer | 473 | 52987.0 | 3 | UniProt (Q2N0S6) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
| 3 | H, D, J | Fab 2C09 heavy chain | polymer | 232 | 24761.8 | 3 | Homo sapiens | ||
| 4 | L, E, K | Fab 2C09 light chain | polymer | 214 | 23281.8 | 3 | Homo sapiens | ||
| 5 | b, M, q | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 3 | In PDB GlyTouCan (G22768VO) | |||
| 6 | 0, 1, c, 2, d... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 36 | In PDB GlyTouCan (G42666HT) | |||
| 7 | g, R, v | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 3 | In PDB GlyTouCan (G56014GC) | |||
| 8 | a, 4, p | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 9 | A, B, C, F, G... | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 15 | Chemie (NAG) |
Sequence modifications
A, B, F: 512 - 664 (UniProt: Q2N0S7)
C, G, I: 31 - 505 (UniProt: Q2N0S6)
| PDB | External Database | Details |
|---|---|---|
| Cys 605 | Thr 602 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 201 | Ile 200 | engineered mutation |
| Asn 332 | Thr 330 | engineered mutation |
| Cys 433 | Ala 430 | engineered mutation |
| Cys 501 | Ala 498 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 354579.1 | |
| Branched | Number of molecules | 45 |
| Total formula weight | 22989.4 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 3318.1 | |
| All* | Total formula weight | 380886.6 |
