8G4N
Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA, Zolpidem, and endogenous neurosteroids
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 455 | 51818.5 | 2 | UniProt (P62812) Pfam (PF02931) Pfam (PF02932) | Mus musculus (house mouse) | GABA(A) receptor subunit alpha-1 |
| 2 | B, E (B, E) | Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 512 | 59265.3 | 2 | UniProt (P63137) Pfam (PF02931) Pfam (PF02932) | Mus musculus (house mouse) | GABA(A) receptor subunit beta-2 |
| 3 | D (D) | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 474 | 55160.3 | 1 | UniProt (P22723) Pfam (PF02931) Pfam (PF02932) | Mus musculus (house mouse) | GABA(A) receptor subunit gamma-2 |
| 4 | F, G (H, J) | Heavy Chain of 8E3 Fab | polymer | 223 | 24159.9 | 2 | Mus musculus | ||
| 5 | H, I (K, L) | Light Chain of 8E3 Fab | polymer | 213 | 23624.1 | 2 | Mus musculus | ||
| 6 | J (O) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K, L, N, O, P (M, R, U, F, G) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 8 | M (I) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 9 | KA, Q (C, A) | allopregnanolone | non-polymer | 318.5 | 2 | Chemie (Y4B) PubChem (16401409) PubChem (16627169) PubChem (16757968) PubChem (16760022) PubChem (16760287) PubChem (21139953) PubChem (1773722) PubChem (176488741) PubChem (176777040) PubChem (176777044) PubChem (22833567) PubChem (22833568) PubChem (24212108) PubChem (24779610) PubChem (24779613) PubChem (24779614) PubChem (24820761) PubChem (25245122) PubChem (25565568) PubChem (40469627) PubChem (40768279) PubChem (31402) PubChem (31403) PubChem (44292263) PubChem (44353728) PubChem (44560336) PubChem (92786) PubChem (28467543) PubChem (53663094) PubChem (228491) PubChem (262961) PubChem (57347399) PubChem (57685076) PubChem (58483179) PubChem (59006263) PubChem (440700) PubChem (70248040) PubChem (70943339) PubChem (71027190) PubChem (637623) PubChem (76311376) PubChem (76318597) PubChem (76318598) PubChem (76322304) PubChem (76325932) PubChem (92787) PubChem (90350189) PubChem (90350294) PubChem (90350296) PubChem (104881) PubChem (70691343) PubChem (90472846) PubChem (126968710) PubChem (129162403) PubChem (10710716) PubChem (6603974) PubChem (6708605) PubChem (100932874) PubChem (7002334) PubChem (102018289) PubChem (102018290) PubChem (7092504) PubChem (7092506) PubChem (9797082) PubChem (11876039) PubChem (9818458) PubChem (9840015) PubChem (9883500) PubChem (9905091) PubChem (9948910) PubChem (10136689) PubChem (10180176) PubChem (10829394) PubChem (124303612) PubChem (124351367) PubChem (124351409) PubChem (124386245) PubChem (11876040) PubChem (11876041) PubChem (12986457) PubChem (124896971) PubChem (124896972) PubChem (124896973) PubChem (124896974) PubChem (124896975) PubChem (146156852) PubChem (153568472) PubChem (125109017) PubChem (166704132) PubChem (126968841) PubChem (129162721) PubChem (130324510) PubChem (133053873) PubChem (133687030) PubChem (134692758) PubChem (134879707) PubChem (138113550) PubChem (140570087) PubChem (141963286) PubChem (145168867) PubChem (145168873) PubChem (145168905) PubChem (145168948) PubChem (146343129) PubChem (153356015) PubChem (155131021) PubChem (158050162) PubChem (163335521) PubChem (163436164) PubChem (164512665) PubChem (165153998) PubChem (166687922) PubChem (166704095) PubChem (166704118) PubChem (166990925) PubChem (172011966) PubChem (172399955) PubChem (172873994) PubChem (173306941) | |||
| 10 | JA, R (C, A) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) PubChem (16219852) PubChem (52946598) PubChem (49867504) PubChem (53394310) PubChem (73441659) PubChem (124587602) PubChem (131850384) PubChem (132274717) PubChem (99649229) PubChem (9543520) PubChem (136212530) PubChem (136212534) | |||
| 11 | AA, BA, BB, CA, DA... (B, E, C, A, D) | DODECANE | non-polymer | 170.3 | 17 | Chemie (D12) PubChem (8182) PubChem (5359624) | |||
| 12 | CB, EB, FB, GB, IB... (E, C, A, D) | N-OCTANE | non-polymer | 114.2 | 17 | Chemie (OCT) PubChem (356) | |||
| 13 | GA, JB, RA, SA, Y (B, E, C, A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) PubChem (65167) PubChem (168614) PubChem (6070971) PubChem (5497103) PubChem (6436017) PubChem (6506401) PubChem (10908846) | |||
| 14 | AB, HA (E, C) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) PubChem (119) | |||
| 15 | IA (C) | Zolpidem | non-polymer | 307.4 | 1 | Chemie (R5R) PubChem (5732) | |||
| 16 | TA (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 372895.9 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 6375.8 | |
| Non-Polymers* | Number of molecules | 47 |
| Total formula weight | 11502.9 | |
| All* | Total formula weight | 390774.6 |
