8G2Q
Structure of Ternary Complex of mouse cGAS with dsDNA and Bound GTP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Cyclic GMP-AMP synthase | polymer | 364 | 42639.3 | 2 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) In PDB | Mus musculus (house mouse) | cGAMP synthase,cGAS,m-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
2 | E, F, I, J | Palindromic DNA18 | polymer | 18 | 5514.6 | 4 | synthetic construct | ||
3 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 4 | Chemie (GTP) | |||
4 | A, C | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | A, C | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
6 | water | water | 18.0 | 148 | Chemie (HOH) |
Sequence modifications
A, C: 147 - 507 (UniProt: Q8C6L5)
PDB | External Database | Details |
---|---|---|
Gly 144 | - | expression tag |
Thr 145 | - | expression tag |
Gly 146 | - | expression tag |
Asn 307 | Asp 307 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 107336.9 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2272.1 | |
All* | Total formula weight | 109609.1 |