8G2G

Crystal structure of PRMT3 with compound YD1113

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Protein arginine N-methyltransferase 3	polymer	340	38281.9	2	UniProt (O60678) Pfam (PF06325) Pfam (PF22528)	Homo sapiens (human)	Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3
2	C, F (A, B)	5'-S-[2-(benzylcarbamamido)ethyl]-5'-thioadenosine	non-polymer		459.5	2	Chemie (YVU)
3	D, E (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	G, H (A, B)	water	water		18.0	163	Chemie (HOH)

Sequence modifications

A, B: 211 - 531 (UniProt: O60678)

PDB	External Database	Details
Met 192	-	initiating methionine
Gly 193	-	expression tag
Ser 194	-	expression tag
Ser 195	-	expression tag
His 196	-	expression tag
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
Ser 202	-	expression tag
Ser 203	-	expression tag
Gly 204	-	expression tag
Leu 205	-	expression tag
Val 206	-	expression tag
Pro 207	-	expression tag
Arg 208	-	expression tag
Gly 209	-	expression tag
Ser 210	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76563.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1111.2
All*	Total formula weight	77675.0

*Water molecules are not included.