8FYX
Buspirone-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 354 | 40414.0 | 1 | UniProt (P63096) Pfam (PF00503) In PDB | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 358 | 39418.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 80 | 8506.8 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (human) | G gamma-I |
4 | R | Soluble cytochrome b562,5-hydroxytryptamine receptor 1A,5-hydroxytryptamine receptor 1A | polymer | 552 | 61375.9 | 1 | UniProt (P08908) Pfam (PF07361) Pfam (PF00001) UniProt (by SIFTS) (P0ABE7) In PDB | Homo sapiens (human) | 5-HT-1A,5-HT1A,G-21,Serotonin receptor 1A |
5 | R | Buspirone | non-polymer | 385.5 | 1 | Chemie (YLX) | |||
6 | R | [(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5E,8E)-hexadeca-5,8,11,14-tetraenoate | non-polymer | 854.9 | 1 | Chemie (J40) | |||
7 | R | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 2 | Chemie (Y01) |
Sequence modifications
A: 1 - 354 (UniProt: P63096)
B: 2 - 340 (UniProt: P62873)
G: 1 - 71 (UniProt: P59768)
R: -129 - 25 (PDB: 8FYX)
R: 26 - 422 (UniProt: P08908)
PDB | External Database | Details |
---|---|---|
Asn 47 | Ser 47 | engineered mutation |
Ala 203 | Gly 203 | engineered mutation |
Ala 245 | Glu 245 | engineered mutation |
Ser 326 | Ala 326 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -17 | - | expression tag |
His -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
Leu -10 | - | expression tag |
Glu -9 | - | expression tag |
Val -8 | - | expression tag |
Leu -7 | - | expression tag |
Phe -6 | - | expression tag |
Gln -5 | - | expression tag |
Gly -4 | - | expression tag |
Pro -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 72 | - | expression tag |
Ser 73 | - | expression tag |
Ala 74 | - | expression tag |
Gly 75 | - | expression tag |
Ser 76 | - | expression tag |
Ala 77 | - | expression tag |
Gly 78 | - | expression tag |
Ser 79 | - | expression tag |
Ala 80 | - | expression tag |
R: 26 - 422 (UniProt: P08908)
PDB | External Database | Details |
---|---|---|
Trp 125 | Leu 125 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 149714.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 2213.8 | |
All* | Total formula weight | 151928.7 |