8FYJ
Structure of HIV-1 BG505 SOSIP-HT2 in complex with two CD4 molecules (class I)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Envelope glycoprotein gp160 | polymer | 474 | 53193.2 | 2 | UniProt (Q2N0S5) Pfam (PF00516) UniProt (by SIFTS) (Q2N0S6) | Human immunodeficiency virus 1 | Env polyprotein |
| 2 | C (C) | Envelope glycoprotein gp160 | polymer | 474 | 53235.4 | 1 | UniProt (Q2N0S5) Pfam (PF00516) | Human immunodeficiency virus 1 | Env polyprotein |
| 3 | D, E, F (D, E, F) | Envelope glycoprotein gp41 | polymer | 153 | 17146.5 | 3 | UniProt (Q2N0S6) Pfam (PF00517) | Human immunodeficiency virus 1 | Env polyprotein |
| 4 | G, H (Y, Z) | T-cell surface glycoprotein CD4 | polymer | 379 | 42325.5 | 2 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) Pfam (PF09191) | Homo sapiens (human) | T-cell surface antigen T4/Leu-3 |
| 5 | I, L, P (G, J, N) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 3 | In PDB GlyTouCan (G81315DD) | |||
| 6 | J (H) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 7 | K, N, O, Q (I, L, M, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 8 | M (K) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | R, S, T, U, V... (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) |
Sequence modifications
A, B: 33 - 508 (UniProt: Q2N0S5)
C: 33 - 508 (UniProt: Q2N0S5)
D, E, F: 512 - 664 (UniProt: Q2N0S6)
Y, Z: 1 - 371 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Trp 315 | Ala 313 | conflict |
| Asn 332 | Thr 330 | conflict |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Trp 316 | Ala 313 | conflict |
| Asn 332 | Thr 330 | conflict |
| Arg 368 | Asp 366 | engineered mutation |
| Cys 501 | Ala 498 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Pro 559 | Ile 556 | conflict |
| Cys 605 | Thr 602 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 372 | - | expression tag |
| Ser 373 | - | expression tag |
| His 374 | - | expression tag |
| His 375 | - | expression tag |
| His 376 | - | expression tag |
| His 377 | - | expression tag |
| His 378 | - | expression tag |
| His 379 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 295712.2 | |
| Branched | Number of molecules | 9 |
| Total formula weight | 5278.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1548.5 | |
| All* | Total formula weight | 302539.5 |
