8FXX

Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (heptameric ring)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, D, F, I... (A, B, D, F, I...)	CPXV040 protein	polymer	204	23396.4	7	UniProt (Q8QN22) Pfam (PF04887)	Cowpox virus (Brighton Red)
2	C, E, G, H, J... (C, E, G, H, J...)	T-lymphocyte activation antigen CD86	polymer	110	12849.6	7	UniProt (P42081) Pfam (PF07686)	Homo sapiens (human)	Activation B7-2 antigen,B70,BU63,CTLA-4 counter-receptor B7.2,FUN-1
3	AA, BA, CA, DA, EA... (I, K, M, A, B...)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	21	Chemie (NAG)

Sequence modifications

A, B, D, F, I, K, M: -3 - 197 (UniProt: Q8QN22)

PDB	External Database	Details
Lys -6	-	expression tag
Pro -5	-	expression tag
Glu -4	-	expression tag

C, E, G, H, J, L, N: 1 - 109 (UniProt: P42081)

PDB	External Database	Details
Met 0	-	initiating methionine

Contents of the asymmetric unit

Polymers	Number of chains	14
	Total formula weight	253722.2
Non-Polymers*	Number of molecules	21
	Total formula weight	4645.4
All*	Total formula weight	258367.6

*Water molecules are not included.