8FWW

Structure of the ligand-binding and transmembrane domains of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344 and noncompetitive inhibitor perampanel

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor ionotropic, kainate 2	polymer	908	102510.0	4	UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Norway rat)	GluK2,Glutamate receptor 6,GluR-6,GluR6
2	E, G, H, J	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	4	In PDB GlyTouCan (G42666HT)
3	F, I	beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G31886NL)
4	B, A	4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide	non-polymer		242.3	4	Chemie (2J9)
5	B, C, A, D	(2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate	non-polymer		760.1	16	Chemie (POV)
6	C, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
7	C, A	2-(6'-oxo-1'-phenyl[1',6'-dihydro[2,3'-bipyridine]]-5'-yl)benzonitrile	non-polymer		349.4	2	Chemie (6ZP)
8	B, C, D, A	SODIUM ION	non-polymer		23.0	7	Chemie (NA)
9	C, A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)

Sequence modifications

A, B, C, D: 1 - 908 (UniProt: P42260)

PDB	External Database	Details
Val 567	Ile 567	conflict
Cys 571	Tyr 571	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	410039.9
Branched	Number of molecules	6
	Total formula weight	3195.0
Non-Polymers*	Number of molecules	33
	Total formula weight	14503.3
All*	Total formula weight	427738.2

*Water molecules are not included.