8FWQ

Structure of kainate receptor GluK2 in complex with the positive allosteric modulator BPAM344

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor ionotropic, kainate 2	polymer	908	102510.0	4	UniProt (P42260) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (Norway rat)	GluK2,Glutamate receptor 6,GluR-6,GluR6
2	E, G, J, L, N...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	8	In PDB GlyTouCan (G42666HT)
3	F, O	beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G44266EX)
4	H, K, M, Q, T...	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	6	In PDB GlyTouCan (G15407YE)
5	I, R	beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G31886NL)
6	B, C, D, A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	14	Chemie (NAG)
7	A, B, C, D	4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide	non-polymer		242.3	4	Chemie (2J9)
8	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)

Sequence modifications

A, B, C, D: 1 - 908 (UniProt: P42260)

PDB	External Database	Details
Val 567	Ile 567	conflict
Cys 571	Tyr 571	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	410039.9
Branched	Number of molecules	18
	Total formula weight	9584.9
Non-Polymers*	Number of molecules	19
	Total formula weight	4089.0
All*	Total formula weight	423713.8

*Water molecules are not included.