8FVL
PCSK9 in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proprotein convertase subtilisin/kexin type 9 | polymer | 152 | 17035.5 | 1 | UniProt (Q8NBP7) Pfam (PF05922) | Homo sapiens (human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
| 2 | B (B) | Proprotein convertase subtilisin/kexin type 9 | polymer | 540 | 57443.7 | 1 | UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) | Homo sapiens (human) | Neural apoptosis-regulated convertase 1,NARC-1,Proprotein convertase 9,PC9,Subtilisin/kexin-like protease PC9 |
| 3 | C (L) | YBX-YC3-VAL-PRO-THR-THR-PHE-MAA-CYS-MN1 inhibitor | polymer | 10 | 1234.5 | 1 | BIRD (PRD_002521) | synthetic construct | |
| 4 | D, E, F (A, B, L) | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
B: 153 - 692 (UniProt: Q8NBP7)
| PDB | External Database | Details |
|---|---|---|
| Ile 474 | Val 474 | variant |
| Glu 670 | Gly 670 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 75713.7 | |
| All* | Total formula weight | 75713.7 |
