8FV3
EGFR(T790M/V948R) in complex with compound 1 (LN4503)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (D, A, B, C) | Epidermal growth factor receptor | polymer | 328 | 37479.4 | 4 | UniProt (P00533) Pfam (PF07714) | Homo sapiens (human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
| 2 | E, G, I (D, A, B) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | F, H, J (D, A, B) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 3 | Chemie (ANP) | |||
| 4 | K (C) | N-{(4P)-4-[(4P)-5-{3-[(8-fluoro-11-oxo-5,11-dihydro-10H-dibenzo[b,e][1,4]diazepin-10-yl)methyl]phenyl}-2-(methylsulfanyl)-1H-imidazol-4-yl]pyridin-2-yl}acetamide | non-polymer | 564.6 | 1 | Chemie (YA6) | |||
| 5 | L, M, N, O (D, A, B, C) | water | water | 18.0 | 335 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 695 - 1022 (UniProt: P00533)
| PDB | External Database | Details |
|---|---|---|
| Met 790 | Thr 790 | engineered mutation |
| Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 149917.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2156.1 | |
| All* | Total formula weight | 152073.6 |
