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8FR4

Carbonic Anhydrase IX-mimic in complex with the alkyl urea compound 3j

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Carbonic anhydrase 2polymer25728844.51UniProt (P00918)
Pfam (PF00194)
Homo sapiens (human)Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II
2B
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
3C
(A)
4-hydroxy-3-{[(4-hydroxybutyl)carbamoyl]amino}benzene-1-sulfonamidenon-polymer303.31Chemie (N7S)
4D
(A)
GLYCEROLnon-polymer92.11Chemie (GOL)
5E
(A)
waterwater18.0208Chemie (HOH)
Sequence modifications
A: 4 - 261 (UniProt: P00918)
PDBExternal DatabaseDetails
Ser 65Ala 65engineered mutation
Gln 67Asn 67engineered mutation
Thr 69Glu 69engineered mutation
Leu 91Ile 91engineered mutation
Val 131Phe 130engineered mutation
Glu 170Lys 169engineered mutation
Ala 204Leu 203engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight28844.5
Non-Polymers*Number of molecules3
Total formula weight460.8
All*Total formula weight29305.3
*Water molecules are not included.

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PDB entries from 2025-02-05

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