8FR0
LBD conformation 3 (LBDconf3) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 150mM NaCl, 330uM CTZ, and 100mM glutamate (Open-Na260)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Glutamate receptor 2 | polymer | 889 | 99559.5 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
2 | A, B, C, D | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
3 | A, B, C, D | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
4 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -20 - 868 (UniProt: P19491)
PDB | External Database | Details |
---|---|---|
Asp 848 | Tyr 869 | engineered mutation |
Tyr 849 | - | insertion |
Lys 850 | - | insertion |
Asp 851 | - | insertion |
Asp 852 | - | insertion |
Asp 853 | - | insertion |
Asp 854 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 398237.8 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 2148.0 | |
All* | Total formula weight | 400385.9 |