8FQ3
LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform N619K mutant of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg/N619K)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, C, D, A | Glutamate receptor 2 | polymer | 889 | 99574.5 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | B, C, D, A | GLUTAMIC ACID | non-polymer | 147.1 | 4 | Chemie (GLU) | |||
| 3 | B, C, D, A | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) | |||
| 4 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
B, C, D, A: -20 - 868 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Lys 619 | Asn 640 | engineered mutation |
| Asp 848 | - | insertion |
| Tyr 849 | - | insertion |
| Lys 850 | - | insertion |
| Asp 851 | - | insertion |
| Asp 852 | - | insertion |
| Asp 853 | - | insertion |
| Asp 854 | Tyr 869 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 398298.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2148.0 | |
| All* | Total formula weight | 400446.2 |
