8FPK
LBD conformation 1 of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, C, A, D | Glutamate receptor 2 | polymer | 889 | 99559.5 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB | Rattus norvegicus (Norway rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | B, C, A, D | 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione | non-polymer | 236.2 | 4 | Chemie (Y4Y) | |||
| 3 | B, C, A, D | CYCLOTHIAZIDE | non-polymer | 389.9 | 4 | Chemie (CYZ) |
Sequence modifications
B, C, A, D: -20 - 868 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Asp 848 | - | insertion |
| Tyr 849 | - | insertion |
| Lys 850 | - | insertion |
| Asp 851 | - | insertion |
| Asp 852 | - | insertion |
| Asp 853 | - | insertion |
| Asp 854 | Tyr 869 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 398237.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2504.2 | |
| All* | Total formula weight | 400742.1 |
