8FP1
PKCeta kinase domain in complex with compound 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein kinase C eta type | polymer | 353 | 40563.0 | 1 | UniProt (P24723) Pfam (PF00069) Pfam (PF00433) | Homo sapiens (human) | PKC-L,nPKC-eta |
| 2 | B (A) | (3P)-3-[6-chloro-4-(9-methyl-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]benzonitrile | non-polymer | 422.9 | 1 | Chemie (XXF) | |||
| 3 | C (A) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 333 - 683 (UniProt: P24723)
| PDB | External Database | Details |
|---|---|---|
| Gly 331 | - | expression tag |
| Ser 332 | - | expression tag |
| Glu 675 | Ser 675 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40563.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 422.9 | |
| All* | Total formula weight | 40985.9 |
