8FOI
Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and allopregnanolone
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Gamma-aminobutyric acid receptor subunit alpha-1 | polymer | 455 | 51818.5 | 2 | UniProt (P62812) Pfam (PF02931) Pfam (PF02932) | Mus musculus (house mouse) | GABA(A) receptor subunit alpha-1 |
| 2 | B, E (B, E) | Gamma-aminobutyric acid receptor subunit beta-2 | polymer | 512 | 59265.3 | 2 | UniProt (P63137) Pfam (PF02931) Pfam (PF02932) | Mus musculus (house mouse) | GABA(A) receptor subunit beta-2 |
| 3 | D (D) | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 474 | 55160.3 | 1 | UniProt (P22723) Pfam (PF02931) Pfam (PF02932) | Mus musculus (house mouse) | GABA(A) receptor subunit gamma-2 |
| 4 | F, G (H, J) | Heavy Chain of 8E3 Fab | polymer | 223 | 24159.9 | 2 | Mus musculus | ||
| 5 | H, I (K, L) | Light Chain of 8E3-Fab | polymer | 213 | 23624.1 | 2 | Mus musculus | ||
| 6 | J (F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G07617FP) | |||
| 7 | K, L, M, O, P (G, I, M, O, P) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 8 | N (N) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 9 | IA, Q (C, A) | [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | non-polymer | 746.6 | 2 | Chemie (PIO) | |||
| 10 | AB, BA, CA, CB, DA... (E, B, C, A, D) | DODECANE | non-polymer | 170.3 | 17 | Chemie (D12) | |||
| 11 | BB, DB, EB, FB, HB... (E, C, D, A) | N-OCTANE | non-polymer | 114.2 | 17 | Chemie (OCT) | |||
| 12 | IB, OA, PA, X, Y (E, C, A) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) | |||
| 13 | Z, ZA (B, E) | GAMMA-AMINO-BUTANOIC ACID | non-polymer | 103.1 | 2 | Chemie (ABU) | |||
| 14 | AA, YA (B, E) | allopregnanolone | non-polymer | 318.5 | 2 | Chemie (Y4B) | |||
| 15 | QA (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 372895.9 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 6375.8 | |
| Non-Polymers* | Number of molecules | 46 |
| Total formula weight | 11195.5 | |
| All* | Total formula weight | 390467.2 |
