8FO8
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 dimer state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ras-related protein Rab-7L1 | polymer | 177 | 20239.1 | 2 | UniProt (O14966) Pfam (PF00071) | Homo sapiens (human) | Rab-7-like protein 1,Ras-related protein Rab-29 |
| 2 | C, D (C, E) | Leucine-rich repeat serine/threonine-protein kinase 2 | polymer | 2527 | 286427.7 | 2 | UniProt (Q5S007) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) | Homo sapiens (human) | Dardarin |
| 3 | E, G (C, E) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
| 4 | F, H (C, E) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) |
Sequence modifications
A, B: 1 - 177 (UniProt: O14966)
C, E: 1 - 2527 (UniProt: Q5S007)
| PDB | External Database | Details |
|---|---|---|
| Leu 67 | Gln 67 | conflict |
| Ala 71 | Thr 71 | conflict |
| Ala 72 | Ser 72 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His 50 | Arg 50 | conflict |
| Thr 1647 | Ser 1647 | conflict |
| Thr 2397 | Met 2397 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 613333.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1900.8 | |
| All* | Total formula weight | 615234.2 |
