8FO8

Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 dimer state

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Ras-related protein Rab-7L1	polymer	177	20239.1	2	UniProt (O14966) Pfam (PF00071) In PDB	Homo sapiens (human)	Rab-7-like protein 1,Ras-related protein Rab-29
2	C, E	Leucine-rich repeat serine/threonine-protein kinase 2	polymer	2527	286427.7	2	UniProt (Q5S007) Pfam (PF13855) Pfam (PF08477) Pfam (PF16095) Pfam (PF00069) In PDB	Homo sapiens (human)	Dardarin
3	C, E	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
4	C, E	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

A, B: 1 - 177 (UniProt: O14966)

PDB	External Database	Details
Leu 67	Gln 67	conflict
Ala 71	Thr 71	conflict
Ala 72	Ser 72	conflict

C, E: 1 - 2527 (UniProt: Q5S007)

PDB	External Database	Details
His 50	Arg 50	conflict
Thr 1647	Ser 1647	conflict
Thr 2397	Met 2397	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	613333.5
Non-Polymers*	Number of molecules	4
	Total formula weight	1900.8
All*	Total formula weight	615234.2

*Water molecules are not included.