8FNO
Structure of E138K/G140A/Q148R HIV-1 intasome with Dolutegravir bound
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, G... (A, B, C, D, G...) | Lamina-associated polypeptide 2, isoforms beta/gamma,Integrase | polymer | 364 | 39941.5 | 8 | UniProt (P42167) UniProt (P12497) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) UniProt (by SIFTS) (P42166) | Homo sapiens (human) | Thymopoietin,isoforms beta/gamma,TP beta/gamma,Thymopoietin-related peptide isoforms beta/gamma,TPRP isoforms beta/gamma,IN |
| 2 | E, K (E, K) | DNA (27-MER) | polymer | 27 | 8188.3 | 2 | Human immunodeficiency virus 1 | ||
| 3 | F, L (F, L) | DNA (25-MER) | polymer | 25 | 7773.0 | 2 | Human immunodeficiency virus 1 | ||
| 4 | M, N, Q, R (A, G) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 5 | O, S (A, G) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 6 | P, T (F, L) | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | non-polymer | 419.4 | 2 | Chemie (DLU) | |||
| 7 | AA, BA, CA, DA, EA... (G, H, I, J, K...) | water | water | 18.0 | 890 | Chemie (HOH) |
Sequence modifications
A, B, C, D, G, H, I, J: -55 - -3 (UniProt: P42167)
A, B, C, D, G, H, I, J: 1 - 288 (UniProt: P12497)
| PDB | External Database | Details |
|---|---|---|
| Gly -75 | - | expression tag |
| Ser -74 | - | expression tag |
| His -73 | - | expression tag |
| Met -72 | - | expression tag |
| Pro -71 | - | expression tag |
| Lys -70 | - | expression tag |
| Arg -69 | - | expression tag |
| Gly -68 | - | expression tag |
| Arg -67 | - | expression tag |
| Pro -66 | - | expression tag |
| Ala -65 | - | expression tag |
| Ala -64 | - | expression tag |
| Thr -63 | - | expression tag |
| Glu -62 | - | expression tag |
| Val -61 | - | expression tag |
| Lys -60 | - | expression tag |
| Ile -59 | - | expression tag |
| Pro -58 | - | expression tag |
| Lys -57 | - | expression tag |
| Pro -56 | - | expression tag |
| Gly -54 | Asn 49 | conflict |
| Gln -17 | Arg 86 | conflict |
| Gly -2 | - | linker |
| Gly -1 | - | linker |
| Gly 0 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Lys 138 | Glu 1285 | engineered mutation |
| Ala 140 | Gly 1287 | engineered mutation |
| Arg 148 | Gln 1295 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 351454.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1066.8 | |
| All* | Total formula weight | 352521.5 |
