8FNL
Structure of E138K/Q148K HIV-1 intasome with Dolutegravir bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, G... | Lamina-associated polypeptide 2, isoform alpha,Integrase chimera | polymer | 364 | 39899.5 | 8 | UniProt (P42166) UniProt (P12497) Pfam (PF02022) Pfam (PF00665) Pfam (PF00552) In PDB | Homo sapiens | Thymopoietin isoform alpha,TP alpha,Thymopoietin-related peptide isoform alpha,TPRP isoform alpha,IN |
2 | E, K | DNA (27-MER) | polymer | 27 | 8188.3 | 2 | Human immunodeficiency virus 1 | ||
3 | F, L | DNA (25-MER) | polymer | 25 | 7773.0 | 2 | Human immunodeficiency virus 1 | ||
4 | A, G | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
5 | A, G | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
6 | F, L | (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide | non-polymer | 419.4 | 2 | Chemie (DLU) | |||
7 | water | water | 18.0 | 590 | Chemie (HOH) |
Sequence modifications
A, B, C, D, G, H, I, J: -53 - -3 (UniProt: P42166)
A, B, C, D, G, H, I, J: 1 - 288 (UniProt: P12497)
PDB | External Database | Details |
---|---|---|
Gly -75 | - | expression tag |
Ser -74 | - | expression tag |
His -73 | - | expression tag |
Met -72 | - | expression tag |
Pro -71 | - | expression tag |
Lys -70 | - | expression tag |
Arg -69 | - | expression tag |
Gly -68 | - | expression tag |
Arg -67 | - | expression tag |
Pro -66 | - | expression tag |
Ala -65 | - | expression tag |
Ala -64 | - | expression tag |
Thr -63 | - | expression tag |
Glu -62 | - | expression tag |
Val -61 | - | expression tag |
Lys -60 | - | expression tag |
Ile -59 | - | expression tag |
Pro -58 | - | expression tag |
Lys -57 | - | expression tag |
Pro -56 | - | expression tag |
Arg -55 | - | expression tag |
Gly -54 | - | expression tag |
Gln -17 | Arg 86 | conflict |
Gly -2 | - | linker |
Gly -1 | - | linker |
Gly 0 | - | linker |
PDB | External Database | Details |
---|---|---|
Lys 138 | Glu 1285 | engineered mutation |
Lys 148 | Gln 1295 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 351118.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1066.8 | |
All* | Total formula weight | 352185.2 |