8FNB

Crystal structure of the C-terminal Fg domain of human TNC with the mutations Y2140H and S2164H

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Tenascin	polymer	231	26413.4	2	UniProt (P24821) Pfam (PF00147) In PDB	Homo sapiens (human)	TN,Cytotactin,GMEM,GP 150-225,Glioma-associated-extracellular matrix antigen,Hexabrachion,JI,Myotendinous antigen,Neuronectin,Tenascin-C,TN-C
2	A, B	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
3	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4		water	water		18.0	433	Chemie (HOH)

Sequence modifications

A, B: 1975 - 2201 (UniProt: P24821)

PDB	External Database	Details
Gly 1971	-	expression tag
Thr 1972	-	expression tag
Gly 1973	-	expression tag
Ser 1974	-	expression tag
His 2140	Tyr 2140	engineered mutation
His 2164	Ser 2164	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	52826.7
Non-Polymers*	Number of molecules	4
	Total formula weight	272.3
All*	Total formula weight	53099.0

*Water molecules are not included.