8FMQ

Complex structure of K210 deletion Troponin complex with alendronate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Troponin C, slow skeletal and cardiac muscles	polymer	164	18673.6	2	UniProt (P63316) Pfam (PF13833) Pfam (PF13499)	Homo sapiens (human)	TN-C
2	B, E (B, E)	Troponin T, cardiac muscle	polymer	108	12971.8	2	UniProt (P45379) Pfam (PF00992)	Homo sapiens (human)	TnTc,Cardiac muscle troponin T,cTnT
3	C, F (C, F)	Troponin I, cardiac muscle	polymer	135	15405.9	2	UniProt (P19429) Pfam (PF00992)	Homo sapiens (human)	Cardiac troponin I
4	G, H, I, J, K... (A, D)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)

Sequence modifications

A, D: 1 - 161 (UniProt: P63316)

PDB	External Database	Details
Gln -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Ser 35	Cys 35	conflict
Ser 84	Cys 84	conflict
Glu 115	Asp 115	conflict

B, E: 183 - 287 (UniProt: P45379)

PDB	External Database	Details
Gln 180	-	expression tag
Gly 181	-	expression tag
Ser 182	-	expression tag
-	Lys 220	deletion

C, F: 32 - 166 (UniProt: P19429)

PDB	External Database	Details
Ala 80	Cys 80	conflict
Ala 97	Cys 97	conflict

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	94102.7
Non-Polymers*	Number of molecules	6
	Total formula weight	240.5
All*	Total formula weight	94343.1

*Water molecules are not included.