8FLH
Bruton's tyrosine kinase in complex with an orthosteric inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase BTK | polymer | 283 | 32680.5 | 1 | UniProt (Q06187) Pfam (PF07714) | Homo sapiens (human) | Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase |
| 2 | B, C (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 3 | D (A) | 2-(3,5-dichloroanilino)-1-{(3R)-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]azepan-1-yl}ethan-1-one | non-polymer | 447.4 | 1 | Chemie (Y8H) | |||
| 4 | E (A) | water | water | 18.0 | 305 | Chemie (HOH) |
Sequence modifications
A: 382 - 659 (UniProt: Q06187)
| PDB | External Database | Details |
|---|---|---|
| Gly 377 | - | expression tag |
| Pro 378 | - | expression tag |
| Leu 379 | - | expression tag |
| Gly 380 | - | expression tag |
| Ser 381 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32680.5 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 603.6 | |
| All* | Total formula weight | 33284.1 |
