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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8FKR

Human nucleolar pre-60S ribosomal subunit (State B1)

This is a non-PDB format compatible entry.
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(BA)		60S ribosomal protein L12polymer16517847.61UniProt (P30050)
Pfam (PF03946)
Pfam (PF00298)		Homo sapiens (human)Large ribosomal subunit protein uL11
2B
(L1)		5.8S rRNApolymer15750449.81GenBank (555853)Homo sapiens (human)
3C
(L2)		ITS2 rRNApolymer1167376425.31GenBank (86475748)Homo sapiens (human)
4D
(L3)		28S rRNApolymer50701640222.11GenBank (86475748)Homo sapiens (human)
5E
(L6)		60S ribosomal protein L13polymer21124321.71UniProt (P26373)
Pfam (PF01294)		Homo sapiens (human)Breast basic conserved protein 1,Large ribosomal subunit protein eL13
6F
(L7)		60S ribosomal protein L13apolymer20323633.41UniProt (P40429)
Pfam (PF00572)		Homo sapiens (human)23 kDa highly basic protein,Large ribosomal subunit protein uL13
7G
(L8)		60S ribosomal protein L14polymer21523485.01UniProt (P50914)
Pfam (PF01929)		Homo sapiens (human)CAG-ISL 7,Large ribosomal subunit protein eL14
8H
(L9)		60S ribosomal protein L15polymer20424207.31UniProt (P61313)
Pfam (PF00827)		Homo sapiens (human)Large ribosomal subunit protein eL15
9I
(LA)		60S ribosomal protein L17polymer18421443.21UniProt (P18621)
Pfam (PF00237)		Homo sapiens (human)60S ribosomal protein L23,Large ribosomal subunit protein uL22,PD-1
10J
(LB)		60S ribosomal protein L18polymer18821687.71UniProt (Q07020)
Pfam (PF17135)		Homo sapiens (human)Large ribosomal subunit protein eL18
11K
(LC)		60S ribosomal protein L18apolymer17620808.51UniProt (Q02543)
Pfam (PF01775)		Homo sapiens (human)Large ribosomal subunit protein eL20
12L
(LE)		60S ribosomal protein L21polymer16018610.01UniProt (P46778)
Pfam (PF01157)		Homo sapiens (human)Large ribosomal subunit protein eL21
13M
(LG)		60S ribosomal protein L23polymer14014892.51UniProt (P62829)
Pfam (PF00238)		Homo sapiens (human)60S ribosomal protein L17,Large ribosomal subunit protein uL14
14N
(LH)		60S ribosomal protein L23apolymer15617740.21UniProt (P62750)
Pfam (PF03939)
Pfam (PF00276)		Homo sapiens (human)Large ribosomal subunit protein uL23
15O
(LI)		60S ribosomal protein L26polymer14517303.41UniProt (P61254)
Pfam (PF16906)
Pfam (PF00467)		Homo sapiens (human)Large ribosomal subunit protein uL24
16P
(LK)		60S ribosomal protein L27apolymer14816604.51UniProt (P46776)
Pfam (PF00828)		Homo sapiens (human)Large ribosomal subunit protein uL15
17Q
(LN)		60S ribosomal protein L3polymer40346224.11UniProt (P39023)
Pfam (PF00297)		Homo sapiens (human)HIV-1 TAR RNA-binding protein B,TARBP-B,Large ribosomal subunit protein uL3
18R
(LQ)		60S ribosomal protein L32polymer13515898.91UniProt (P62910)
Pfam (PF01655)		Homo sapiens (human)Large ribosomal subunit protein eL32
19S
(LS)		60S ribosomal protein L35polymer12314593.61UniProt (P42766)
Pfam (PF00831)		Homo sapiens (human)Large ribosomal subunit protein uL29
20T
(LT)		60S ribosomal protein L35apolymer11012564.71UniProt (P18077)
Pfam (PF01247)		Homo sapiens (human)Cell growth-inhibiting gene 33 protein,Large ribosomal subunit protein eL33
21U
(LU)		60S ribosomal protein L36polymer10512290.91UniProt (Q9Y3U8)
Pfam (PF01158)		Homo sapiens (human)Large ribosomal subunit protein eL36
22V
(LW)		60S ribosomal protein L37polymer9711111.01UniProt (P61927)
Pfam (PF01907)		Homo sapiens (human)G1.16
23W
(NB)		Guanine nucleotide-binding protein-like 3polymer54962098.21UniProt (Q9BVP2)
Pfam (PF08701)
Pfam (PF01926)		Homo sapiens (human)E2-induced gene 3 protein,Novel nucleolar protein 47,NNP47,Nucleolar GTP-binding protein 3,Nucleostemin
24X
(NE)		Surfeit locus protein 6polymer36141553.81UniProt (O75683)
Pfam (PF04935)		Homo sapiens (human)
25Y
(NF)		Ribosome biogenesis protein NSA2 homologpolymer26030136.71UniProt (O95478)
Pfam (PF01201)		Homo sapiens (human)Hairy cell leukemia protein 1,TGF-beta-inducible nuclear protein 1
26Z
(NG)		RRP15-like proteinpolymer28231539.31UniProt (Q9Y3B9)
Pfam (PF07890)		Homo sapiens (human)Ribosomal RNA-processing protein 15
27AA
(NM)		Protein MAK16 homologpolymer30035469.71UniProt (Q9BXY0)
Pfam (PF01778)
Pfam (PF04874)		Homo sapiens (human)NNP78,Protein RBM13
28BA
(NN)		Suppressor of SWI4 1 homologpolymer47353292.11UniProt (Q9NQ55)
Pfam (PF04427)		Homo sapiens (human)Ssf-1,Brix domain-containing protein 3,Peter Pan homolog
29CA
(NO)		Ribosomal RNA processing protein 1 homolog Apolymer46152927.31UniProt (P56182)
Pfam (PF05997)		Homo sapiens (human)Novel nuclear protein 1,NNP-1,Nucleolar protein Nop52,RRP1-like protein
30DA
(NQ)		WD repeat-containing protein 74polymer38542501.21UniProt (Q6RFH5)
Pfam (PF00400)		Homo sapiens (human)NOP seven-associated protein 1
31EA
(NS)		Ribosome production factor 1polymer34940189.01UniProt (Q9H9Y2)
Pfam (PF04427)		Homo sapiens (human)Brix domain-containing protein 5,Ribosome biogenesis protein RPF1
32FA
(SA)		60S ribosomal protein L4polymer42747804.61UniProt (P36578)
Pfam (PF00573)
Pfam (PF14374)		Homo sapiens (human)60S ribosomal protein L1,Large ribosomal subunit protein uL4
33GA
(SC)		60S ribosomal protein L6polymer28832810.21UniProt (Q02878)
Pfam (PF03868)
Pfam (PF01159)		Homo sapiens (human)Large ribosomal subunit protein eL6,Neoplasm-related protein C140,Tax-responsive enhancer element-binding protein 107,TaxREB107
34HA
(SD)		60S ribosomal protein L7polymer24829291.01UniProt (P18124)
Pfam (PF08079)
Pfam (PF00327)		Homo sapiens (human)Large ribosomal subunit protein uL30
35IA
(SE)		60S ribosomal protein L7apolymer26630061.81UniProt (P62424)
Pfam (PF01248)		Homo sapiens (human)Large ribosomal subunit protein eL8,PLA-X polypeptide,Surfeit locus protein 3
36JA
(SG)		60S ribosomal protein L9polymer19221899.51UniProt (P32969)
Pfam (PF00347)		Homo sapiens (human)Large ribosomal subunit protein uL6
37KA
(SH)		MKI67 FHA domain-interacting nucleolar phosphoproteinpolymer29334285.31UniProt (Q9BYG3)
Pfam (PF00076)
Pfam (PF12196)		Homo sapiens (human)Nucleolar phosphoprotein Nopp34,Nucleolar protein interacting with the FHA domain of pKI-67,hNIFK
38LA
(SI)		60S ribosomal protein L7-like 1polymer25529730.41UniProt (Q6DKI1)
Pfam (PF08079)
Pfam (PF00327)		Homo sapiens (human)Large ribosomal subunit protein uL30-like 1
39MA
(SJ)		pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3polymer84796726.91UniProt (Q8IY81)
Pfam (PF01728)
Pfam (PF11861)
Pfam (PF07780)		Homo sapiens (human)Protein ftsJ homolog 3,Putative rRNA methyltransferase 3
40NA
(SK)		Eukaryotic translation initiation factor 6polymer24526620.01UniProt (P56537)
Pfam (PF01912)		Homo sapiens (human)eIF-6,B(2)GCN homolog,B4 integrin interactor,CAB,p27(BBP)
41OA
(SL)		Ribosomal L1 domain-containing protein 1polymer49055089.81UniProt (O76021)
Pfam (PF00687)		Homo sapiens (human)CATX-11,Cellular senescence-inhibited gene protein,Protein PBK1
42PA
(SM)		Pescadillo homologpolymer58868114.71UniProt (O00541)
Pfam (PF06732)
Pfam (PF16589)		Homo sapiens (human)
43QA
(SN)		Probable rRNA-processing protein EBP2polymer30634925.11UniProt (Q99848)
Pfam (PF05890)		Homo sapiens (human)EBNA1-binding protein 2,Nucleolar protein p40
44RA
(SO)		Ribosome biogenesis protein BRX1 homologpolymer35341483.51UniProt (Q8TDN6)
Pfam (PF04427)		Homo sapiens (human)Brix domain-containing protein 2
45SA
(SQ)		mRNA turnover protein 4 homologpolymer23927602.51UniProt (Q9UKD2)
Pfam (PF00466)
Pfam (PF17777)		Homo sapiens (human)Ribosome assembly factor MRTO4
46TA
(SR)		GTP-binding protein 4polymer63474107.81UniProt (Q9BZE4)
Pfam (PF17835)
Pfam (PF06858)
Pfam (PF08155)		Homo sapiens (human)Chronic renal failure gene protein,GTP-binding protein NGB,Nucleolar GTP-binding protein 1
47UA
(SS)		Ribosome biogenesis protein BOP1polymer74683901.51UniProt (Q14137)
Pfam (PF08145)
Pfam (PF00400)		Homo sapiens (human)Block of proliferation 1 protein
48VA
(ST)		Ribosome biogenesis regulatory protein homologpolymer36541278.51UniProt (Q15050)
Pfam (PF04939)		Homo sapiens (human)
49WA
(SV)		Probable ribosome biogenesis protein RLP24polymer16319666.31UniProt (Q9UHA3)
Pfam (PF01246)		Homo sapiens (human)Ribosomal L24 domain-containing protein 1,Ribosomal protein L24-like
50XA
(SW)		ATP-dependent RNA helicase DDX18polymer67075526.81UniProt (Q9NVP1)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF13959)		Homo sapiens (human)DEAD box protein 18,Myc-regulated DEAD box protein,MrDb
51YA
(SZ)		Nucleolar protein 16polymer17821234.51UniProt (Q9Y3C1)
Pfam (PF09420)		Homo sapiens (human)HBV pre-S2 trans-regulated protein 3
52AB, AC, BB, BC, CB...
(L1, L3, L2, SA, L9...)		MAGNESIUM IONnon-polymer24.354Chemie (MG)
PubChem (888)
53AD, FD
(LW, SV)		ZINC IONnon-polymer65.42Chemie (ZN)
54BD
(NM)		IRON/SULFUR CLUSTERnon-polymer351.61Chemie (SF4)
55DD
(SR)		GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
PubChem (136073927)
PubChem (135398619)
PubChem (135402030)
PubChem (135431654)
PubChem (135566337)
PubChem (135760556)
PubChem (136026707)
PubChem (136053418)
PubChem (136663964)
PubChem (136664748)
PubChem (136759848)
PubChem (136759849)
PubChem (136759850)
PubChem (136836636)
PubChem (136847074)
PubChem (172898537)
56ED
(SR)		POTASSIUM IONnon-polymer39.11Chemie (K)
PubChem (813)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains51
Total formula weight3724233.6
Non-Polymers*Number of molecules59
Total formula weight2277.2
All*Total formula weight3726510.8
*Water molecules are not included.

251422

PDB entries from 2026-04-01

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