8FJA
CryoEM structure of HLA-A2 MAGEA4 (230-239) in complex with REGN6972 Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | REGN6972 Fab light chain | polymer | 214 | 23420.9 | 1 | Homo sapiens (human) | ||
| 2 | B (E) | REGN6972 Fab heavy chain | polymer | 236 | 25272.3 | 1 | Homo sapiens (human) | ||
| 3 | C (A) | MHC class I antigen | polymer | 277 | 32082.5 | 1 | UniProt (Q861F7) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (human) | |
| 4 | D (B) | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 5 | E (C) | Melanoma-associated antigen 4 peptide | polymer | 10 | 1134.2 | 1 | UniProt (P43358) | Homo sapiens | Cancer/testis antigen 1.4,CT1.4,MAGE-4 antigen,MAGE-41 antigen,MAGE-X2 antigen |
Sequence modifications
A: 1 - 276 (UniProt: Q861F7)
B: 1 - 99 (UniProt: P61769)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 93789.3 | |
| All* | Total formula weight | 93789.3 |
