8FH6
Crystal Structure Of Aldose Reductase (AKR1B1) Complexed With NADP+ And Two AT-001
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldo-keto reductase family 1 member B1 | polymer | 316 | 35914.3 | 1 | UniProt (P15121) Pfam (PF00248) | Homo sapiens (human) | Aldehyde reductase,Aldose reductase,AR |
| 2 | B (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) | |||
| 3 | C, D (A) | (8-oxo-7-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-7,8-dihydropyrazino[2,3-d]pyridazin-5-yl)acetic acid | non-polymer | 421.4 | 2 | Chemie (XXQ) | |||
| 4 | E, F, G (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 5 | H (A) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35914.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1772.3 | |
| All* | Total formula weight | 37686.7 |
