8FGZ
Crystal structure of mutant Androgen Receptor ligand binding domain L702H/H875Y/F877L with DHT
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Androgen receptor | polymer | 258 | 30110.2 | 1 | UniProt (P10275) Pfam (PF00104) | Homo sapiens (human) | Dihydrotestosterone receptor,Nuclear receptor subfamily 3 group C member 4 |
| 2 | B (A) | 5-ALPHA-DIHYDROTESTOSTERONE | non-polymer | 290.4 | 1 | Chemie (DHT) PubChem (16395945) PubChem (1779160) PubChem (23729584) PubChem (44264584) PubChem (44307156) PubChem (44308180) PubChem (44314545) PubChem (1779165) PubChem (1779163) PubChem (44403751) PubChem (54132599) PubChem (57253355) PubChem (2748143) PubChem (11302) PubChem (968803) PubChem (6951009) PubChem (124916763) PubChem (67080676) PubChem (68213431) PubChem (70627790) PubChem (133612463) PubChem (11869360) PubChem (15) PubChem (76333143) PubChem (10635) PubChem (90350225) PubChem (147320) PubChem (16111632) PubChem (667503) PubChem (928651) PubChem (124305346) PubChem (124335861) PubChem (124350819) PubChem (124362930) PubChem (124402106) PubChem (124420348) PubChem (124907326) PubChem (124907327) PubChem (6432518) PubChem (7052570) PubChem (7052571) PubChem (9965809) PubChem (134753818) PubChem (10379482) PubChem (10902374) PubChem (11860392) PubChem (11867857) PubChem (11867858) PubChem (11867859) PubChem (11867860) PubChem (11869358) PubChem (11869359) PubChem (11869361) PubChem (11914201) PubChem (11920866) PubChem (139564330) PubChem (141909893) PubChem (142776876) PubChem (145087815) PubChem (12446746) PubChem (12446747) PubChem (12446748) PubChem (12446749) PubChem (12446752) PubChem (156740897) PubChem (162854571) PubChem (162854572) PubChem (162854573) PubChem (164663566) PubChem (165146196) PubChem (165431280) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 663 - 920 (UniProt: P10275)
| PDB | External Database | Details |
|---|---|---|
| His 702 | Leu 702 | engineered mutation |
| Tyr 875 | His 875 | engineered mutation |
| Leu 877 | Phe 877 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30110.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 482.6 | |
| All* | Total formula weight | 30592.7 |
