8FGW
Human IFT-A complex structures provide molecular insights into ciliary transport
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | WD repeat-containing protein 35 | polymer | 1181 | 133705.6 | 1 | UniProt (Q9P2L0) Pfam (PF00400) Pfam (PF12894) | Homo sapiens (human) | Intraflagellar transport protein 121 homolog |
| 2 | B (B) | Intraflagellar transport protein 122 homolog | polymer | 1241 | 141993.7 | 1 | UniProt (Q9HBG6) Pfam (PF00400) | Homo sapiens (human) | WD repeat-containing protein 10,WD repeat-containing protein 140 |
| 3 | C (C) | WD repeat-containing protein 19 | polymer | 1342 | 151760.4 | 1 | UniProt (Q8NEZ3) Pfam (PF00400) Pfam (PF15911) | Homo sapiens (human) | Intraflagellar transport 144 homolog |
| 4 | D (D) | Tetratricopeptide repeat protein 21B | polymer | 1316 | 151137.4 | 1 | UniProt (Q7Z4L5) Pfam (PF13181) Pfam (PF14559) Pfam (PF13176) | Homo sapiens (human) | TPR repeat protein 21B,Intraflagellar transport 139 homolog |
| 5 | E (E) | Intraflagellar transport protein 140 homolog | polymer | 1462 | 165404.3 | 1 | UniProt (Q96RY7) | Homo sapiens (human) | WD and tetratricopeptide repeats protein 2 |
| 6 | F (F) | Intraflagellar transport protein 43 homolog | polymer | 208 | 23558.1 | 1 | UniProt (Q96FT9) Pfam (PF15305) | Homo sapiens (human) | |
| 7 | G, H, I, J, K (A, B, C) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
B: 1 - 1241 (UniProt: Q9HBG6)
D: 1 - 1316 (UniProt: Q7Z4L5)
| PDB | External Database | Details |
|---|---|---|
| Asp 238 | Glu 238 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met 201 | Val 201 | variant |
| Ala 276 | Thr 276 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 767559.5 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 327.0 | |
| All* | Total formula weight | 767886.6 |
