8FG1

Human diaphanous inhibitory domain bound to diaphanous autoregulatory domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Protein diaphanous homolog 1	polymer	256	29116.4	1	UniProt (O60610) Pfam (PF06371) Pfam (PF06367)	Homo sapiens (human)	Diaphanous-related formin-1,DRF1
2	B (B)	Protein diaphanous homolog 1	polymer	29	3161.5	1	UniProt (O60610) Pfam (PF06345)	Homo sapiens (human)	Diaphanous-related formin-1,DRF1

Sequence modifications

A: 142 - 380 (UniProt: O60610)

PDB	External Database	Details
Met 125	-	initiating methionine
Gly 126	-	expression tag
Ser 127	-	expression tag
Ser 128	-	expression tag
Glu 129	-	expression tag
Arg 130	-	expression tag
Ser 131	-	expression tag
His 132	-	expression tag
His 133	-	expression tag
His 134	-	expression tag
His 135	-	expression tag
His 136	-	expression tag
His 137	-	expression tag
Ser 138	-	expression tag
Gly 139	-	expression tag
Ser 140	-	expression tag
Glu 141	-	expression tag

B: 1194 - 1142 (UniProt: O60610)

PDB	External Database	Details
Leu 1199	Met 1199	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	32277.9
All*	Total formula weight	32277.9

*Water molecules are not included.