8FFW
Cryo-EM structure of the GR-Hsp90-FKBP51 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-alpha | polymer | 731 | 84650.5 | 2 | UniProt (P07900) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (human) | Heat shock 86 kDa,HSP 86,HSP86,Lipopolysaccharide-associated protein 2,LAP-2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C (C) | Glucocorticoid receptor | polymer | 360 | 41199.0 | 1 | UniProt (P04150) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 3 | D (D) | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 456 | 51159.0 | 1 | UniProt (Q13451) Pfam (PF00254) Pfam (PF00515) | Homo sapiens (human) | PPIase FKBP5,51 kDa FK506-binding protein,51 kDa FKBP,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
| 4 | E, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | I (C) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) PubChem (16757640) PubChem (21140858) PubChem (3003) PubChem (176476476) PubChem (176476477) PubChem (176481066) PubChem (176519880) PubChem (176541415) PubChem (5743) PubChem (24758428) PubChem (24848023) PubChem (40467076) PubChem (40469527) PubChem (40469528) PubChem (40469529) PubChem (40469538) PubChem (40469540) PubChem (18609236) PubChem (46870667) PubChem (134645) PubChem (146915) PubChem (51529018) PubChem (51723203) PubChem (51723204) PubChem (53316140) PubChem (56627169) PubChem (40467075) PubChem (57959704) PubChem (57959709) PubChem (59499751) PubChem (59553041) PubChem (45791747) PubChem (60032782) PubChem (60107679) PubChem (60107685) PubChem (60113881) PubChem (60129028) PubChem (66739593) PubChem (67968282) PubChem (68163950) PubChem (68346426) PubChem (69301933) PubChem (70211292) PubChem (70834467) PubChem (70965822) PubChem (71083129) PubChem (51654720) PubChem (451600) PubChem (469455) PubChem (656865) PubChem (73707402) PubChem (73945193) PubChem (73950719) PubChem (1150209) PubChem (1426961) PubChem (68625576) PubChem (176476478) PubChem (3036635) PubChem (90141965) PubChem (9782) PubChem (155299) PubChem (71299643) PubChem (969487) PubChem (92043418) PubChem (92259599) PubChem (5702012) PubChem (6432476) PubChem (6546942) PubChem (6604243) PubChem (6603742) PubChem (124301806) PubChem (5702035) PubChem (92259552) PubChem (6610297) PubChem (6610335) PubChem (6710614) PubChem (117072391) PubChem (9830630) PubChem (9865316) PubChem (123132537) PubChem (124190915) PubChem (11014684) PubChem (124304345) PubChem (12358596) PubChem (12358597) PubChem (12358599) PubChem (12358600) PubChem (12358601) PubChem (12358603) PubChem (14697793) PubChem (124904342) PubChem (124904343) PubChem (124918510) PubChem (124918511) PubChem (129010233) PubChem (133634290) PubChem (133645861) PubChem (134990893) PubChem (135396701) PubChem (137704752) PubChem (139404989) PubChem (140662068) PubChem (145705940) PubChem (146436354) PubChem (152964101) PubChem (162730335) PubChem (163285078) PubChem (163285103) PubChem (164010962) PubChem (175434953) PubChem (176282643) |
Sequence modifications
C: 418 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 261659.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1455.4 | |
| All* | Total formula weight | 263114.5 |
