8FFW
Cryo-EM structure of the GR-Hsp90-FKBP51 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Heat shock protein HSP 90-alpha | polymer | 731 | 84650.5 | 2 | UniProt (P07900) Pfam (PF13589) Pfam (PF00183) | Homo sapiens (human) | Heat shock 86 kDa,HSP 86,HSP86,Lipopolysaccharide-associated protein 2,LAP-2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38 |
| 2 | C (C) | Glucocorticoid receptor | polymer | 360 | 41199.0 | 1 | UniProt (P04150) Pfam (PF00105) Pfam (PF00104) | Homo sapiens (human) | GR,Nuclear receptor subfamily 3 group C member 1 |
| 3 | D (D) | Peptidyl-prolyl cis-trans isomerase FKBP5 | polymer | 456 | 51159.0 | 1 | UniProt (Q13451) Pfam (PF00254) Pfam (PF00515) | Homo sapiens (human) | PPIase FKBP5,51 kDa FK506-binding protein,51 kDa FKBP,FKBP-51,54 kDa progesterone receptor-associated immunophilin,Androgen-regulated protein 6,FF1 antigen,FK506-binding protein 5,FKBP-5,FKBP54,p54,HSP90-binding immunophilin,Rotamase |
| 4 | E, G (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 5 | F, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | I (C) | DEXAMETHASONE | non-polymer | 392.5 | 1 | Chemie (DEX) |
Sequence modifications
C: 418 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Ser 602 | Phe 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 261659.0 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1455.4 | |
| All* | Total formula weight | 263114.5 |
